Ab-CoV Database

Ab-CoV Database
 

News: Researchers at the Indian Institute of Technology (IIT) Madras recently developed an online open-source database, ‘Ab-CoV’ of coronaviruses neutralizing antibodies.
 

About:
 It is an online open-source database of coronaviruses’ neutralizing antibodies encompassing crucial features such as binding affinity and neutralization profiles of antibodies.
 It is an exhaustive repository of antibodies, not just specific to SARS CoV-2 but also to other members of the coronavirus family, such as Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) viruses.
 It also contains the source of each antibody and the viral protein(s) and virus strains they recognize.
 Ab-CoV has a wide range of search and display options through which users can directly search and download the processed data based on the antibody's name, viral protein epitope, neutralized viral strain, antibody, and nanobody.
 Applications - antibody engineering, analyzing immune escape for known and future variants of SARS-CoV2, computational studies on neutralizing antibodies and relating structural features with binding affinity.