News: Researchers from Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bengaluru, have developed a small molecule that helps disrupt and reduce formation of amyloid plaques in the brains of mice with Alzheimer’s Disease.
- Alzheimer’s Disease is a progressive and irreversible disorder of the brain, which affects memory and thinking skills.
- Usually, in people, the symptoms start manifesting when they are in their sixties, though the onset is much earlier.
- The World Alzheimer Report 2015 notes that in 2015, over 46 million people worldwide were living with dementia. The report estimated that this number would increase to more than 131.5 million by 2050.
- One main feature of the disease is the deposition of amyloid plaques and neurofibrillary tangles in the brain.
- Amyloid precursor proteins which play a critical role in the formation of the amyloid plaques were targeted by the researchers.
- The candidate molecules TGR60-65 were screened through in vitro and cellular assays and were found to check the growth of amyloid plaques and also dissolve preformed ones.
- The data from these experiments revealed superior activity of TGR63 molecule and this molecule was taken up for further animal studies in mice, which also proved the effectiveness of TGR63 molecule in treating Alzheimer’s Disease in mice. The team observed that the molecule TGR63 reduced amyloid plaques in mice brains and reversed cognitive decline
- The group is planning to take this molecule TGR63, which is a potential drug candidate for Alzheimer’s Disease, forward for clinical studies.